Functions of biomolecules, in particular enzymes, are usually modulated by structural fluctuations.This is especially the case in a gated diffusion-controlled reaction catalyzed by an enzyme such as acetylcholinesterase.The catalytic triad of acetylcholinesterase is located at the bottom of a long and narrow gorge, but it catalyzes the extremely ra

BackgroundThe role of school contacts in the spread of the virus and the effectiveness of school closures in controlling the epidemic is still debated.We aimed to quantify the risk of transmission of SARS-CoV-2 in the school setting by type of school, characteristics of the index case and calendar period in the Province of Reggio Emilia (RE), Italy

The present study investigates the time-use activities of pilgrims at their religious destination.The time diary was used to describe the behaviour of pilgrims who came on a pilgrimage to the holy shrine of opi march in uniform Imam Reza in Mashhad (Iran) in sufficient detail to measure the overall duration and continuous records of activities.Acco

Different from an ordinary project, a large group mission like the unmanned aerial vehicle (UAV) swarm cooperative strike mission is performed by multiple executors and needs to be strictly carried out according to the plan.Because of the complex cooperative relationships between the sub-missions that make up a large mission, a small disturbance ma

Background: Retesting for Human epidermal growth factor receptor-2 (HER2) in post-neoadjuvant therapy resection is variable, and data is conflicting regarding the prognostic significance of changes in HER2 expression pre and post therapy.Methods: We identified 104 patients with localized HER2 IHC 3+ breast cancer who received neoadjuvant trastuzuma